There is nothing attractive about dandruff on your shirt, but luckily aspirin can take care of the pesky flakes. The salicylic acid in aspirin is actually what is used in medicated shampoos that are specifically created to control dandruff. Gafanovich recommends simply adding aspirin to your shampoo. “It exfoliates the scalp, removing the dead skin layers that are responsible for dandruff,” she says. Crush two uncoated aspirins into a powder and combine them with a tablespoon of shampoo.