If you've ever sat down to fill out an NCAA tournament bracket you know how maddening it is when virtual unknown up-ends a contender and completely trashes your predictions. Maybe that's why it's called March Madness. There are almost always upsets but only a few are particularly shocking. Still a No. 16-seed has yet to top a No. 1-seed, the Holy Grail of NCAA upsets, but we've seen a fair share of incredible first round knockoffs and Cinderella runs deep into the tournament by teams we never expected (remember George Mason?). Here are our votes for the top 10.