It’s true: In some cases size does matter. In fact, for many guys, building bigger muscles is the key reason to go the gym. Of course, consuming protein is critical, but according to Washington State University researchers creatine supplementation can also make a difference. Their study determined that participants supplementing with creatine were able to gain significant muscle mass and strength in myogenic satellite cells, which are important in the regeneration and overall maintenance of skeletal muscle. There’s a reason that bodybuilders and powerlifters love creatine, and this is it.