Staying fit and eating healthy—along with getting plenty of shuteye and washing your hands with surgeon-like precision—are some of the most effective ways to avoid a miserable cold or flu. But if you really want to bolster your chances of keeping illness at bay, a little immune system adjustment is in order.

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Arm yourself with these tried-and-true options—proven cold busters effective in clobbering germs that might otherwise turn you into a sniveling, sneezing mess—and check out some newly emerging star players that have been drawing attention lately for their potential cold- and flu-fighting cred.

These are the supplements you need this winter.