Combining acetaminophen with even light amounts of alcohol regularly can raise kidney disease risk by 123%, according to a study of more than 10,000 people. Researchers suggest that alcohol interferes with the gene that regulates the way the body processes the painkiller. If you’re worried about a headache the next day, stick to NSAIDs (nonsteroidal anti-inflammatory drugs) like aspirin or ibuprofen before bed. Better yet, ease up on the elbow-bending altogether: As we’d all agree, the best hangover is no hangover at all.

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