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The Fountain of Youth?

Scientists have discovered the simple way to activate CREB1, the longevity molecule, in the brain.

We are all well aware of the ill effects overeating has on your waistline and your heart, but have you ever stopped to consider what it's doing to your brain? You should. Scientists have discovered that calorie restricted diets activate a molecule, CREB1, which is linked to healthy brain functions and longevity, in the brains of mice. Many studies have already supported that overeating causes the brain to slow down and age faster, but this is the first time scientists have pinpointed the exact cause. A simple low-calorie diet was all it took to cause a spike in CREB1 and keep the brain young. Mice who consumed only 70 percent of their normal intake showed obvious health benefits like less weight gain and lower instances of diabetes, but they also showed better cognition, memory, even temperaments and had lower or less severe instances of neurological diseases like Alzheimer's and Parkinson's in old age. "Thus, our findings identify for the first time an important mediator of the effects of diet on the brain," study leader Dr. Giovambattista Pani said. "This discovery has important implications to develop future therapies to keep our brain young and prevent brain degeneration and the aging process. In addition, our study shed light on the correlation among metabolic diseases as diabetes and obesity and the decline in cognitive activities." It could be the key to the fountain of youth.

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