Putting in the overtime hours might keep your boss happy or help you pay off that holiday credit card bill, but it can take a toll on your health in the long term.

Working 41–48 hours a week instead of a “normal” 35–40 raises your risk of stroke by 10%; toiling 49–54 hours ups it by 27%; and slaving away for 55 hours hoists it by a shocking 33%, according to a new study from University College London.

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The mega-analysis of 25 previous studies involving some half a million adults in the U.S., Europe, and Australia just confirms what we’ve always said: Sometimes the smartest four words a man can say are “Time to go home.” 

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